Caloric restriction and intermittent fasting: two potential diets for successful brain aging
Martin B, Mattson MP, Maudsley S.
Laboratory of Neurosciences,
National Institute on Aging Intramural Research Program,
5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
Ageing Res Rev. 2006 Aug;5(3):332-53.
ABSTRACTThe vulnerability of the nervous system to advancing age is all too often manifest in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review article we describe evidence suggesting that two dietary interventions, caloric restriction (CR) and intermittent fasting (IF), can prolong the health-span of the nervous system by impinging upon fundamental metabolic and cellular signaling pathways that regulate life-span. CR and IF affect energy and oxygen radical metabolism, and cellular stress response systems, in ways that protect neurons against genetic and environmental factors to which they would otherwise succumb during aging. There are multiple interactive pathways and molecular mechanisms by which CR and IF benefit neurons including those involving insulin-like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator-activated receptors. These pathways stimulate the production of protein chaperones, neurotrophic factors and antioxidant enzymes, all of which help cells cope with stress and resist disease. A better understanding of the impact of CR and IF on the aging nervous system will likely lead to novel approaches for preventing and treating neurodegenerative disorders.Carnitine
Free radicals and ageing
Caloric restriction mimetics
CR/age-related oxidative damage
Caloric Restriction: humans vs nonhumans
Demographics of supercentenarians in the early 21st C
Cardiovascular and cerebrovascular benefits of IF and CR
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