Life extension in Drosophila by feeding a drug
by
Kang HL, Benzer S, Min KT.
Neurogenetics Branch, MSC1250, 10/3B12,
National Institute of Neurological Disorders and Stroke,
National Institutes of Health,
Bethesda, MD 20892, USA.
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):838-43
ABSTRACTWe report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.4 phenylbutyrate
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